Energizer HPE 40 is a polyphenolic non-vitamin nutriceutical/pharmaceutical antioxidant of a new generation, with no toxic or other side effects, accompanied by pronouncedly strong antioxidant activity. In the dose of 500 mg (one capsule) it is approximately 540 times more effective than the same dose of vitamin E. It effectively protects all proteins against the oxidative damages, and thus, contributes to the extension of healthy life.
Energizer HPE 40 is expected to have a positive impact in the prevention of aging process and in the risk reduction of incurable age-related diseases such as neurodegenerative, cardiovascular, malignant and autoimmune diseases.
Energizer HPE 40 is a unique compound of four natural pharmacologically active ingredients (API's) with exceptional antioxidant properties '96 Resveratrol, Oligomeric proanthocyanidins (OPC), Lycopene and Epigallocatechin gallate (EGCG), and Silica earth which is used as a stabilizer and radical cations neutralizer. Biochemical effect of all ingredients is additionally enhanced due to their synergism accomplished through innovative biotechnological production process. Therefore, the Energizer HPE 40 is presently a unique antioxidant on the market.
Owing to its thoroughly selected composition, which has been worked out based on hundreds of scientific mechanism-of-action studies with the used active pharmaceutical ingredients, as well as characteristics of the production process and up-to-date results of the product researches we can justifiably conclude that every-day use of only 1 capsule of our Energizer HPE 40 provides efficient and complete antioxidant protection.
ACTIVE PHARMACEUTICAL INGREDIENTS
Resveratrol is a phenolic compound, a part of the family of flavonoids, which can be found in the grape seeds, red wine, walnuts, peanuts, etc. Potential positive effects of this powerful antioxidant on human health have been the subject of hundreds of scientific studies in the past 20 years. In particular, they have shown that resveratrol:
- protects lipids against peroxidative damage and, in a dose-dependent manner, prevents oxidized LDL from entering the vascular wall (the key stage in the development of atherosclerosis)
- inhibits production of eicosanoids such as prostaglandins, thromboxanes and leucotrienes, compounds involved in inflammatory reactions and platelet aggregation
- appears to reduce secretion of VLDL by the liver, thus preventing hepatic metabolism of lipoproteins
- stops the proliferation of cells in the blood vessels which restrict the lumen of cancer
- prevents many stages of carcinogenesis and appears to fight cancer in a number of ways, from blocking estrogens to modulating genes
- destroys cancer cells and boosts certain chemotherapies
- its anti-inflammatory action is as effective as that of the drug Prednisone, with the additional benefit of providing free radical protection
- it inhibits the release of inflammatory cytokines in obstructive pulmonary disease, making it an effective treatment for this lung disorder
- protects the brain from free radical attack and from beta-amyloid neurotoxicity
- activates the '91longevity gene'92 - its effects mimic those of caloric restriction, the only proven way to increase maximum lifespan
- it activates '93anti-aging'94 enzyme SIRT12 which then activates Sirtuin 1 gene.
Oligomeric procyanidins (OPCs) are flavonoids present in the grape seed extract, red grapes, peanuts, coconuts, apples, etc. They provide protection against endogenous and exogenous sources of oxidative stress and support the normal metabolic processes. Their antioxidant effect is up to 50 times higher compared to vitamin E and C. The studies have shown that OPCs:
- may help protect against the effects of internal and environmental stresses such as cigarette smoking and pollution, as well as supporting normal body metabolic processes
- help prevent and repair capillary damage
- may be useful to treat heart diseases such in a way to depress blood fat, emolliate blood vessels, lower blood pressure, prevent blood vessel scleroses, drop blood viscidity and prevent thrombus formation
- may reduce risk of heart disease by inhibiting platelet aggregation and reducing inflammation (by limiting lipid oxidation)
- may interfere with cancer cell growth and proliferation, as well as induce apoptosis
- may also be active against HIV by inhibiting virus expression and replication
- induce vascular endothelial growth factor and accelerated healing of injured skin in mice
- may inhibit oral sugar metabolism and retard growth of certain bacteria causing dental caries
- enhance bone density and strength in experimental animals
- decrease skin tumor numbers and reduced the malignancy of papillomas
- may protect against skin carcinogenesis and provide supplementation for sunscreen protection
- help treat chronic venous insufficiency and edema.
Epigallocatechin gallate (EGCG) is the most abundant catechin in tea and is a potent antioxidant and anti-inflammatory substance that may have therapeutic applications in the treatment of many disorders. Its pharmacologic activity extends beyond its action as an antioxidant. EGCG has been shown to:
- decreases the production of inflammatory prostaglandin E2
- decreases the risk of developing atherosclerosis
- decreases arterial inflammation, i.e., the chances of sticky build up on the artery walls
- reduces the levels of LDL ('93bad'94) cholesterol and raise HDL ("good") cholesterol, thereby reducing the risk of coronary heart disease
- inhibit lipid peroxidation
- prevents skin damage and skin cancer
- acts against urokinase, an enzyme often found in large amounts in human cancers
- inhibits ornithine decarboxylase (a rate-limiting enzyme closely associated with tumor promotion)
- blocks type 1 5-alpha reductase (5AR)
- attaches to urokinase and prevents the breakage of the basement membrane of cell junctions which may be a key step in the process of tumor cell metastasis
- inhibits the growth of breast cancer cells, colorectal carcinoma cells, all three pancreatic carcinoma cells (PANC-1, MIA PaCa-2 and BxPC-3), and non-Hodgkin's lymphoma cells
- reduces risk of lung cancer and Bladder cancer, and induces prostate cancer and stomach cancer apoptosis (programmed cell death)
- may help prevent the onset and growth of skin tumors
- may prevent UV-B-induced immunosuppression and precancerous cell changes after UV-B exposure
- reactivates dying skin cells
- prevents the development of type 1 diabetes and slow the progression once it has developed
- may help treat viral hepatitis (inflammation of the liver from a virus)
- kills dangerous intestinal bacterial strains (Clostridium and Escherichia coli) and promotes the growth of friendly bacteria in the intestine.
Lycopene is a bright red carotenoid pigment and phytochemical found in tomatoes and other red fruits. Tomatoes are one of the major constituents of the Mediterranean diet and epidemiological studies have suggested that people who have a diet rich in tomatoes have a decreased risk of cardiovascular disease. Lycopene is helpful in the:
- cardiovascular diseases (atherosclerosis, risk of heart stroke, flexibility and thickening of blood vessels)
- reduction of the oxidation of LDL (bad) cholesterol
- diabetes
- cancer prevention, particularly prostate cancer
- enlarged prostate
- prevention of skin damage and skin cancer.
Silica earth (Diatomaceous earth) is a soft siliceous solid composed of the skeletons of small prehistoric aquatic plants and it contains primarily silica. Silica earth has been used as an aid in the clearance of digestive parasites in animals for many years and it is also used as an aid to human digestion. Therefore, it is safe for human consumption.
Silica earth comprises complex microscopic structure with an enormous surface area (up to 1000 m2/g) and has cation bonding capacity. It can bind to and so eliminate free radicals. Although the area of effect for the silica earth is largely limited to the gastrointestinal tract, it can significantly reduce the resulting damage to biological structures by free radicals, such as lipid peroxidation of intestinal cell membranes and oxidation of genomic DNA.
Additionally, silica earth can stabilize API particles ('93ship in the bottle'94 effect) and protected them from the:
- oxidation
- loss of catalytic characteristic, and
- transport of oxygen.
Thus, their long-term chemical and biological stability, as well as slow release with higher intrinsic activity is achieved.
http://en.wikipedia.org/wiki/Diatomaceous_earth